JOSTON Bio-Pharma Machine Bioreactor Gmp Solution Preparation System

Stainless Steel High-Efficient Steam Jacketed Solution Mixing Production Line

This Stainless Steel High-Efficient Steam Jacketed Solution Mixing Production Line is designed for high-quality, efficient solution mixing, with a range of customizable components to meet the needs of various production processes.

Key Units and Components:

Manufacturing Tank (Mixing Tank):

• Jacketed mixing tank equipped with either top-mounted or bottom-mounted agitators for effective mixing.

Pre-Filter:

• Used for filtering particles or suspensions, located between the mixing tank and storage tank. Options include micropore filters or press filters, depending on product requirements.

Transfer Pump:

• Sanitary grade centrifuge pump used to transfer the solution from the mixing tank to the storage tank.

Storage Tank:

• Used for storing the mixed solution before the filling and packaging process.

Final Stage Filter:

• Typically a micropore filter, used before the solution is transferred to the filling machine.

Optional Equipment:

• High shear emulsifying pump or high-pressure homogenizer for suspension or syrup products.

Pipeline & Valve System:

• For the smooth transfer and control of liquids throughout the production process.

Control Panel System:

• PLC/HMI control system or standard button control panel for user-friendly operation.

SS304 Platform:

• Stainless steel platform for supporting the solution preparation system.

Advantages of the PLC/HMI Control System:

Aseptic Design:

• Minimizes residue by ensuring no dead areas in the system.

PLC Control:

• Touchscreen interface with one-key operation, clear process flow chart, automatic liquid distribution, and material transfer throughout the system. Simple, convenient, and user-friendly.

CIP/SIP System:

• Features automatic online Cleaning-In-Place (CIP) and Sterilization-In-Place (SIP) systems, reducing production costs and manual effort.

Automatic Filter Integrity Check:

• The system automatically checks filter integrity online for continuous operation.

Real-Time Weight and Volume Detection:

• Continuous monitoring and automatic adjustment of weight and volume during the mixing process.

Data Recording and Reporting:

• The system records and prints all relevant process data for real-time tracking and analysis.

Technical Specifications:

• Working Volume: 20-20,000L
• Materials: SS316L or SS304
• Tank Structure Options: Single-layer, double-layer
• Jacket Structure Options: Full jacket, limpet coil jacket, or dimple jacket
• Heating Medium: Steam, hot water, or electrical heating
• Cooling Medium: Chiller
• Agitator Options:
  • Top-mounted (propeller, anchor, scraper, or high shear emulsifying)
  • Bottom-mounted (magnetic or high shear emulsifying)
• Tank Equipment:
  • Manhole, CIP spray ball, vent filter, sight glass, safety valve, sampling valve, sensors (temperature, pressure, pH, etc.), flush bottom valve, and more.

CIP/SIP System:

• The system includes online CIP/SIP for tank and pipeline cleaning, ensuring hygienic operation and minimal downtime between production runs.

This solution preparation system is ideal for efficient, hygienic, and high-capacity solution mixing across various industries, offering reliable performance with minimal manual intervention.